Mass Spectrometry
Mass Spectrometry System is one of the important facilities of National Center for Protein Science (Shanghai) (NCPSS). The discovery of Electrospray Ionization Mass Spectrometry brings biological, clinical and pharmaceutical research a great breakthrough. Recently Mass Spectrometry further becomes a vital tool, which complement to X-ray, NMR, and Electron Microscopy (EM) in the area of structural biology research. MS Facility provides the best collaboration with both scientific and technical expertise and state-of-the-art high-performance, tandem mass spectrometric instrumentation. Major research focuses within the MS facility are: 1) multi-dimensional protein identification (MudPIT) in large scale, as well as accurate mass measurements of intact proteins, lipids, etc. 2) analysis of non-covalent protein-protein and protein-ligand complexes and supramolecular coordination clusters, 3) analysis of all kinds of post-translational modifications, 4) quantitative analysis of protein expression and post-translational modifications.
 
Significant instrumentation in the facility covers major mass analyzers which includes five Orbitrap mass spectrometers (Thermo two LTQ-Orbitrap Elite (one with electron transfer dissociation (ETD)), one LTQ-XL and two Q Exactives), one MALDI TOF/TOF (AB 5800), one hybrid triple quadrupole linear ion trap (6500 QTrap), three QTOF (Agilent 6530, 6550 and AB 5600 triple tof); and two triple quadrupole (Agilent 6490 and Waters TQS).
333 Haike Road, Pudong District,
201210, Shanghai, P.R.China
Tel: 021-20778500
Email: ncpss@sibcb-ncpss.org